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Exposure to SARS-Cov-2 Within the Household Is Associated with Greater Symptom Severity and Stronger Antibody Responses in a Community-Based Sample of Seropositive Adults (WP-21-20)

Joshua Schrock, Daniel Ryan, Rana Saber, Nanette Benbow, Lauren Vaught, Nina Reiser, Matthew Velez, Ryan Hsieh, Michael Newcomb, Alexis Demonbreun, Brian Mustanski, Elizabeth McNally, Richard D’Aquila, and Thomas McDade

Magnitude of SARS-CoV-2 virus exposure may contribute to symptom severity. In a sample of seropositive adults (n=1101), the researchers found that individuals who lived with a known COVID-19 case exhibited greater symptom severity and IgG concentrations compared to individuals who were seropositive but did not live with a known case (P<0.0001).

Joshua Schrock, Institute for Sexual and Gender Minority Health and Wellbeing, Northwestern University

Daniel Ryan, Institute for Sexual and Gender Minority Health and Wellbeing, Northwestern University

Rana Saber, Institute for Sexual and Gender Minority Health and Wellbeing, Northwestern University

Nanette Benbow, Research Assistant Professor of Psychiatry and Behavioral Sciences, Northwestern University

Lauren Vaught, Center for Genetic Medicine, Northwestern University

Nina Reiser, Center for Genetic Medicine, Northwestern University

Matthew Velez, Center for Genetic Medicine, Northwestern University

Ryan Hsieh, Center for Genetic Medicine, Northwestern University

Michael Newcomb, Associate Professor of Medical Social Sciences, Northwestern University

Alexis Demonbreun, Assistant Professor of Pharmacology, Northwestern University

Brian Mustanski, Professor of Medical Social Sciences and IPR Associate, Northwestern University

Elizabeth McNally, Elizabeth J. Ward Professor of Genetic Medicine, Northwestern University

Richard D’Aquila, Howard Taylor Ricketts, MD, Professor of Medicine, Northwestern University

Thomas McDade, Carlos Montezuma Professor of Anthropology and IPR Fellow, Northwestern University

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